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Sonodynamic Treatment Triggers Cancer Cell Killing by Doxorubicin in P‐Glycoprotein‐Mediated Multidrug Resistant Cancer Models

Doxorubicin is a widely used chemotherapeutic agent that can be hampered in its efficacy by the occurrence of multidrug resistance (MDR), due to the overexpression of the drug efflux transporter P-glycoprotein. As overcoming MDR still remains an unmet clinical need, this work aims at investigating an innovative strategy. Sonodynamic therapy (SDT) selectively kills cancer cells by combining low-intensity ultrasound (US) with a responsive chemical agent (sonosensitiser) that can be activated to...

Combination of US hyperthermia and radiotherapy on a preclinical glioblastoma model

In this work the effect of combining ultrasound (US) hyperthermia (HT) with radiotherapy (RT) was investigated. The treatment was applied to a GBM xenograft nude mouse model obtained by injecting 2×106 U87 luc+ cells. The combined treatment group received 6 Gy and HT at 43∘ for 8 min. The ultrasound field was generated by a closed-loop computationally controlled system, consisting of a High Intensity Focused Ultrasound (HIFU) transducer with centre frequency 3.57 MHz, a power amplifier, a fun...

Site-Controlled Single-Photon Emitters Fabricated by Near-Field Illumination

Many of the most advanced applications of semiconductor quantum dots (QDs) in quantum information technology require a fine control of the QDs' position and confinement potential, which cannot be achieved with conventional growth techniques. Here, a novel and versatile approach for the fabrication of site-controlled QDs is presented. Hydrogen incorporation in GaAsN results in the formation of N–2H and N–2H–H complexes, which neutralize all the effects of N on GaAs, including the N-induced lar...

Multicomponent Synergistic Contribution in Nanoengineered Nanofibers for Flexible Energy Storage

Lightweight and flexible energy storage devices are gaining interest due to their potential integration into wearable electronics. They might work for the long-term powering of sensors, for example, but they need to be operative after the application of different types of mechanical stress. Conductive and semiconducting nanomaterials have been largely investigated as active components for this type of application but need to be coupled to an elastic matrix, such as a polymeric one, in order t...

Determining the Permeability of Porous Bioceramic Scaffolds: Significance, Overview of Current Methods and Challenges Ahead

The "architectural suitability" of scaffolds for bone tissue engineering is commonly evaluated by assessing the pore volume and the mean pore size (or pore size distribution, if possible) and comparing these values with the reference ranges of human cancellous bone. However, these two parameters cannot precisely describe the complex architecture of bone scaffolds and just provide a preliminary comparative criterion. Permeability is suggested as a more comprehensive and significant parameter t...

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